Download Magnetic Resonance Techniques in Clinical Trials in Multiple by M. Filippi, R. I. Grossman, G. Comi (auth.), Massimo PDF
By M. Filippi, R. I. Grossman, G. Comi (auth.), Massimo Filippi, Robert I. Grossman, Giancarlo Comi (eds.)
We have entered a thrilling interval within the learn of a number of sclerosis and its remedy. valuable to this development has been the creation of magnetic reso nance strategies. while younger and his colleagues released the 1st photos of the mind in a number of sclerosis on the finish of 1981, it was once instantaneously visible that magnetic resonance imaging may playa significant function in analysis. Intuitively one felt that it should even have a function in expanding our realizing of the pathogenesis of the illness and in tracking remedy. And so it has proved. very important difficulties besides the fact that stay, probably an important of which at the present is the vulnerable predictive energy of ordinary magnetic resonance ima ging tools in opting for the opportunity of development of impairment and incapacity. lately, there were advances which promise to beat a few of these difficulties, yet judgements approximately what method of undertake in deciding upon sufferers for scientific trials and which concepts to exploit in tracking therapy in the course of their path are nonetheless tough. during this booklet, Dr. Filippi and his colleagues have assembled an excellent crew of members whose paintings is relevant to the growth that's being made. The insurance of the problems curious about using magnetic resonance recommendations in assessing healing impression is finished and, even though the sector is chan ging swiftly, the foundations and lots more and plenty of the aspect within the ebook tend to have lasting value.
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Extra resources for Magnetic Resonance Techniques in Clinical Trials in Multiple Sclerosis
Paty criteria. The criteria developed by Patyet al.  require ~ 4 T2 -hyperintense lesions, or 3 T2 -hyperintense lesions of which one must be in a periventricular location. In two independent studies, the sensitivity and specificity of these criteria were calculated to be 94% and 57% , or 88% and 54% , respectively. 2. Enhancing lesions. If one requires at least one enhancing lesion and one nonenhancing lesion, specificity can be increased (80%), while sensitivity will decrease (59%) .
1998) The prognostic value of brain MRI in clinically isolated syndromes of the CNS. A 10 year follow-up. Brain 121: 495503 14. Beck RW, Cleary PA, Trobe JD, et al. and the Optic Neuritis Study Group (1993) The effect of corticosteroids for acute optic neuritis on the subsequent development of multiple sclerosis. N Engl J Med 329: 1764-1769 15. Miller DH, Albert PS, Barkhof F, et al. (1996) Guidelines for the use of magnetic resonance techniques in monitoring the treatment of multiple sclerosis.
MRI Selection Criteria in Phase II Trials in Relapsing MS The assumption for MRI-based phase II trials is that a significant decrease in activity, defined by enhancing lesions, provides sufficient evidence to warrant further investigation in definitive phase III trials. Negative results from enhancing lesion outcomes would deem further studies less desirable . Activity Enrichment Strategy. MRI can be used as a patient selection criteria in phase II trials to enrich the population for patients with active disease, as defined by the number of enhancing lesions.