Download Bioengineering of the Skin: Water and the Stratum Corneum, by Joachim W. Fluhr, Peter Elsner, Enzo Berardesca, Howard I. PDF
By Joachim W. Fluhr, Peter Elsner, Enzo Berardesca, Howard I. Maibach
Bioengineering of the surface, or extra exactly the biophysical evaluation of dermis body structure, is relocating quickly from a descriptive method of a deeper realizing of biophysical and biochemical procedures. This moment variation of the preferred textual content Bioengineering of the outside: Water and Stratum Corneum displays the development within the box, targeting the dramatically enhanced realizing of epidermis body structure. in particular, it stories the shift in our realizing of the stratum corneum from an inert surrounding sheet to a biologically lively compartment.
The stratum corneum is the interface among the occasionally harsh surroundings and the inner turmoil of the human physique. according to a good number of fresh courses, this publication explains the mechanisms excited about stratum corneum barrier functionality and hydration. It displays 10 years of growth not just of the non-invasive biophysical review of pores and skin body structure parameter, but in addition of the perfection of the to be had units. It brings all learn on epidermal water and transepidermal water loss in well-being and disorder up to date with the revision of present chapters in addition to additional chapters from new participants on hydration and itching. This variation additionally contains new guidance at the standardization of measurements.
Bioengineering of the outside will improve communique in the learn neighborhood and should be worthy for scientists within the pores and skin bioengineering box by means of proposing tools that supply trustworthy and reproducible ways for product trying out within the pharmaceutical and beauty industries, in addition to for simple study
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Bioengineering of the outside, or extra exactly the biophysical evaluate of dermis body structure, is relocating swiftly from a descriptive method of a deeper knowing of biophysical and biochemical methods. This moment version of the preferred textual content Bioengineering of the outside: Water and Stratum Corneum displays the growth within the box, targeting the dramatically better figuring out of dermis body structure.
Additional resources for Bioengineering of the Skin: Water and the Stratum Corneum, 2nd Edition
78. , Handbook of Cosmetic Science and Technology, Marcel Dekker, New York, 1991, 201. 79. , Liposome Dermatics, Springer, Berlin, 1992, 346. 80. , Developments in liposomal drug delivery systems, Expert Opin. Biol. , 1, 923, 2001. 81. B. , Handbook of Cosmetic Science and Technology, Marcel Dekker, New York, 2001, 361. 2 Water–Keratin Interactions Jean-Luc Lévêque CONTENTS I. 15 II. 17 III. 18 IV. 20 V. 21 VI. 21 VII. 22 VIII. 23 IX. 24 I. INTRODUCTION Keratins are a family of proteins produced by certain epidermal cells in higher vertebrates.
Structure of water, proteins and lipids in intact human skin, hair and nail. J. Invest. , 110, 393, 1998. 8. , Lipid themotropic transitions in human stratum corneum. J. Invest. , 86, 255, 1986. 9. , Stratum corneum lipids as a bound water modulator. J. Invest. , 96, 845, 1991. 10. , Are corneocytes elastic? Dermatologica, 176, 65, 1988. 11. , Water-keratin interaction in human stratum corneum, Bioeng. Skin, 3, 227, 1987. 12. , Water sorption by human callus, Biochem. Biophys. Acta, 540, 518, 1978.
Major changes are also seen in both optical  and thermal properties . The equilibrium between keratin and water is thus essential for keratinized tissues to fulfill their role correctly. Our understanding of these interactions is far from complete. As we saw earlier in this chapter, WSMs play an important role in the hydration of the SC. A major advance was made when WSMs were shown to be filaggrin degradation products . Unfortunately we still do not know exactly how these products (mainly amino acids) influence the degree of hydration, but it may involve a direct effect or the facilitation of water molecule access to the hydrophilic sites on keratin.