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Download Biodegradable Polymers as Drug Delivery Systems (Drugs and by Mark Chasin PDF

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By Mark Chasin

Reports the homes, synthesis, and formulations of a couple of good studied polymers more and more getting used in site-specific or systematic management of pharmaceutical brokers. for every of the polymers, discusses the heritage; chemistry and synthesis; the formula of microcapsules, solv

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Extra resources for Biodegradable Polymers as Drug Delivery Systems (Drugs and the Pharmaceutical Sciences)

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The choice of molding pl'ocedure to be used must be tailored to pach drug to h(~ incorporated. Factors to be considered must include the thermal stability of the drug, the potential reactivity of the drug with the polymer chosen, the T m and T g values of the polymer of interest, the importance of porosity on the release kinetics of the drug from the molded product, and the cost limitations and manufacturing scale of the final product. Chasin et al. 46 B. Microsphere Fabrication Techniques For many drug delivery applications, the preferred method of delivery of the dosage form is by injection.

Effect of surgical trauma and polylactate cubes and granules on the incidence of alveolar osteitis in mandibular third molar extraction wounds, Can. Dent. Assoc. , 52, 315, 1986. , Biodegradable implants in fracture fixation: Early results of treatment of fractures of the ankle, Lancet, 1, 1422, 1985. , In vivo fate of bioresorbable bone plates of long-lasting poly(L-lactic acid), Proc. 2nd World Congress on Biomaterial, 279, 1984. Rudolf, R. , Resorbable poly(L-lactide) plates and screws for the fixation of zygomatic fracture, J.

Pearson, J. , and Nazareno, J. , Biodegradable microcapsules: Acceleration of polymeric excipient hydrolytic rate by incorporation of a basic medicament, J. Control. , ~, 103, 1986. Miller, R. , Brady, J. , and Cutright, D. , Degradation rates of oral resorbable implants (polylactates and polyglycolates): Rate modification with changes in PLA/PGA copolymer ratios, J. Biomed. Mater. , g, 711, 1977. Pitt, C. , Gratzel, M. , Kimmel, G. , Aliphatic polyesters. 2. The degradation of 34 37. 38. 39.

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